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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10785
Species: Mus musculus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10affects expressionEXP 6480464CTDParaquat affects the expression of IL10 proteinPMID:28090784
Il10decreases expressionEXP 6480464CTDParaquat results in decreased expression of IL10 mRNA; Paraquat results in decreased expression of IL10 proteinPMID:18441283 PMID:36108500
Il10multiple interactionsEXP 6480464CTD[Resveratrol co-treated with Tetracyclines] affects the reaction [Paraquat affects the expression of IL10 protein]; PTPN6 protein inhibits the reaction [Paraquat results in decreased expression of IL10 protein]PMID:18441283 PMID:28090784
Il10decreases expressionISOIL10 (Homo sapiens)6480464CTDParaquat results in decreased expression of IL10 proteinPMID:22736252 PMID:36108500
Il10increases expressionISOIl10 (Rattus norvegicus)6480464CTDParaquat results in increased expression of IL10 mRNAPMID:19497220
Il10increases expressionISOIL10 (Homo sapiens)6480464CTDParaquat results in increased expression of IL10 mRNAPMID:22230393 PMID:22736252
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTD[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in decreased expression of IL10 protein]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of IL10 mRNA]PMID:22736252
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