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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10132
Species: Mus musculus
RGD Object: Gene
Symbol: Akt2
Name: thymoma viral proto-oncogene 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt2increases response to substanceEXP 6480464CTDAKT2 protein results in increased susceptibility to ParaquatPMID:28115273
Akt2multiple interactionsEXP 6480464CTDAKT2 protein affects the reaction [Paraquat results in decreased expression of PPARGC1A protein]; AKT2 protein affects the reaction [Paraquat results in increased expression of NFE2L2 protein]PMID:28115273
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