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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Aincreases expressionEXP 6480464CTDnickel chloride results in increased expression of IL1A mRNAPMID:11378323 PMID:17312168
IL1Amultiple interactionsEXP 6480464CTD[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1A proteinPMID:18437699
IL1Adecreases expressionISOIl1a (Mus musculus)6480464CTDnickel chloride results in decreased expression of IL1A proteinPMID:23178550
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