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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRincreases expressionEXP 6480464CTDnickel chloride results in increased expression of PGR mRNA; nickel chloride results in increased expression of PGR proteinPMID:12746304
PGRmultiple interactionsEXP 6480464CTDEstradiol promotes the reaction [nickel chloride results in increased expression of PGR mRNA]; Estradiol promotes the reaction [nickel chloride results in increased expression of PGR protein]; fulvestrant inhibits the reaction [nickel chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [nickel chloride results in increased expression of PGR protein]; nickel chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA]; nickel chloride promotes the reaction [Estradiol results in increased expression of PGR protein]PMID:12746304
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