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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDnickel chloride results in decreased expression of CCND1 mRNAPMID:17312168
CCND1decreases phosphorylationEXP 6480464CTDnickel chloride results in decreased phosphorylation of CCND1 proteinPMID:18792914
CCND1multiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased phosphorylation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 proteinPMID:18792914
CCND1affects expressionISOCcnd1 (Rattus norvegicus)6480464CTDnickel chloride affects the expression of CCND1 mRNAPMID:22546817
CCND1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDCHUK protein affects the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 proteinPMID:18792914
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