GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | multiple interactions | EXP | | 6480464 | CTD | [[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein] | PMID:31639282 | Il1b | affects expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | nickel chloride affects the expression of IL1B mRNA | PMID:33774146 | Il1b | decreases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | nickel chloride results in decreased expression of IL1B mRNA | PMID:27427241 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | nickel chloride results in increased expression of IL1B mRNA; nickel chloride results in increased expression of IL1B protein | PMID:36421005 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased expression of IL1B mRNA; nickel chloride results in increased expression of IL1B protein | PMID:11378323 PMID:21569788 PMID:30016632 | Il1b | increases secretion | ISO | Il1b (Mus musculus) | 6480464 | CTD | nickel chloride results in increased secretion of IL1B protein | PMID:19844976 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; CASP1 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL1B mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL1B protein] | PMID:16687389 PMID:24158569 PMID:36421005 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein] which results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; Sodium inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein] | PMID:18437699 PMID:23090859 PMID:24158569 PMID:30016632 PMID:31943712 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |