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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDnickel chloride affects the expression of HMOX1 mRNAPMID:22546817
Hmox1increases expressionEXP 6480464CTDnickel chloride results in increased expression of HMOX1 mRNAPMID:22110744
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDnickel chloride results in increased expression of HMOX1 mRNAPMID:17312168 PMID:17547211 PMID:18830972 PMID:21111804
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HMOX1 mRNA]; nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of HMOX1 mRNA]PMID:16806455 PMID:18830972 PMID:23090859
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