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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf3
Name: colony stimulating factor 3
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13509556480464CTDnickel chloride results in increased expression of CSF3 mRNA

PMID:17312168
multiple interactionsISORGD:13509556480464CTD[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CSF3 protein, nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CSF3 mRNA]

PMID:18437699, PMID:23090859
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.