GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases expression | ISO | Akt1 (Rattus norvegicus) | 152177911 | RGD | N-nitrosodiethylamine increases expression of Akt1 protein in liver in rats | | Akt1 | increases phosphorylation | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased phosphorylation of AKT1 protein | PMID:20583210 | Akt1 | multiple interactions | EXP | | 6480464 | CTD | [Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Diethylnitrosamine inhibits the reaction [Cholic Acid results in increased activity of and results in increased phosphorylation of AKT1 protein]; scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein] | PMID:20583210 PMID:27151938 PMID:37436232 | Akt1 | increases expression | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of AKT1; Diethylnitrosamine results in increased expression of AKT1 mRNA | PMID:17055752 PMID:30423403 | Akt1 | increases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased phosphorylation of AKT1 protein | PMID:30779474 | Akt1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein; Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; neferine inhibits the reaction [Diethylnitrosamine results in increased expression of AKT1 mRNA] | PMID:24990399 PMID:30423403 PMID:30779474 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |