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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733275
Species: Homo sapiens
RGD Object: Gene
Symbol: TFRC
Name: transferrin receptor
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFRCincreases expressionISOTfrc (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of TFRC mRNAPMID:19638242
TFRCincreases expressionISOTfrc (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of TFRC mRNA; Diethylnitrosamine results in increased expression of TFRC proteinPMID:19061943
TFRCmultiple interactionsISOTfrc (Rattus norvegicus)6480464CTD[Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC mRNA; [Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC protein; [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA; [Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC proteinPMID:20302851
TFRCmultiple interactionsISOTfrc (Mus musculus)6480464CTDIron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]PMID:19061943
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