Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179
Species: Homo sapiens
RGD Object: Gene
Symbol: CCNB1
Name: cyclin B1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCNB1increases expressionISOCcnb1 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of CCNB1 mRNAPMID:25242409
CCNB1increases expressionISOCcnb1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CCNB1 mRNAPMID:17854601 PMID:19996281 PMID:24535843
CCNB1multiple interactionsISOCcnb1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 protein; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CCNB1 mRNAPMID:12616621 PMID:18164116 PMID:22129741
CCNB1multiple interactionsISOCcnb1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CCNB1 mRNA; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNB1 mRNA]PMID:17854601 PMID:24535843
Go Back to source page   Continue to Ontology report