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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732061
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK4
Name: cyclin dependent kinase 4
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK4increases expressionISOCdk4 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of CDK4 proteinPMID:11831363 PMID:19822196 PMID:24012840 PMID:26589970
CDK4multiple interactionsISOCdk4 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 protein; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CDK4 protein]PMID:12616621 PMID:17602206 PMID:24012840
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