GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | RB1 | decreases expression | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of RB1 mRNA | PMID:19638242 | RB1 | decreases response to substance | ISO | Rb1 (Mus musculus) | 6480464 | CTD | RB1 protein results in decreased susceptibility to Diethylnitrosamine | PMID:17854601 | RB1 | increases expression | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of RB1 protein | PMID:19822196 | RB1 | multiple interactions | ISO | Rb1 (Mus musculus) | 6480464 | CTD | RB1 protein affects the reaction [Diethylnitrosamine results in increased expression of RBL1 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AEBP2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ANAPC5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPTL2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ANLN mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ASF1B mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATM mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AURKA mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BIRC5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BRCA2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BUB1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CASP8AP2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CBX5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNA2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNA2 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNB1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNB2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNF mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC20 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC25C mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC45 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC6 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA3 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA7 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDCA8 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDK1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDKN1C mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDT1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CENPA mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHAF1B mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CKAP2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CKS1B mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CKS2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CRABP1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DCK mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DEK mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNAJC9 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNM1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNMT1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DOK1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DTYMK mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of E2F1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of E2F1 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ECT2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EGR1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EI24 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EPHX1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ERCC5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ETV4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EZH2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FBLN1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FEN1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FEZ1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FIGNL1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FOXM1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of GJA1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of GMNN mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HAT1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGA2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGB2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGB3 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGN1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGN2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HNRNPU mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IDH2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of INCENP mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF11 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF20A mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF22 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF23 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF2C mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF5A mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LIG1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LMO7 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LTBP4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MAD2L1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MAP4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM3 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM7 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM7 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MRE11A mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MRE11A protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NASP mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NCAPH mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NEK2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NOTCH1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ORC6 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PERP mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PHC1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLTP mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PML mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of POLA1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of POLD1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PRC1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PRDX4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PRIM1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAD21 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAD51 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAD51AP1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RBL1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RBL1 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RFC5 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPA1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SLK mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMC2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMC4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMOC2 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ST3GAL4 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of STMN1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TCF19 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TFDP1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TIPIN mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TK1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMPO mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOP2A mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOPBP1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRIP13 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TTK mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2D mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of TGFB1 mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of SERPINE1 mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of TGFB3 mRNA] | PMID:17854601 PMID:18282651 PMID:19887370 | RB1 | multiple interactions | ISO | Rb1 (Rattus norvegicus) | 6480464 | CTD | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RB1 mRNA; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RB1 mRNA; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RB1 mRNA | PMID:17602206 PMID:18164116 | | ||||||||||||||||||||||
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