GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AHR | decreases expression | ISO | Ahr (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of AHR mRNA | PMID:18282651 | AHR | decreases expression | ISO | Ahr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of AHR protein | PMID:27565560 | AHR | decreases response to substance | ISO | Ahr (Mus musculus) | 6480464 | CTD | AHR protein results in decreased susceptibility to Diethylnitrosamine | PMID:19996281 | AHR | increases expression | ISO | Ahr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of AHR mRNA | PMID:27565560 | AHR | multiple interactions | ISO | Ahr (Mus musculus) | 6480464 | CTD | [Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein affects the reaction [Diethylnitrosamine affects the expression of APAF1 mRNA]; AHR protein affects the reaction [Diethylnitrosamine results in increased expression of IL6 protein]; AHR protein affects the reaction [Diethylnitrosamine results in increased expression of TNF mRNA]; AHR protein affects the reaction [Diethylnitrosamine results in increased expression of TNF protein]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of APAF1 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2C mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DNMT1 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of HDAC1 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of MCM7 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SIRT1 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP73 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC25B mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of SERPINE1 mRNA]; AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB2 mRNA]; AHR protein promotes the reaction [Diethylnitrosamine results in increased expression of IL6 mRNA]; Diethylnitrosamine promotes the reaction [AHR protein binds to CYP1A1 promoter] | PMID:15535986 PMID:19690152 PMID:19996281 | AHR | multiple interactions | ISO | Ahr (Rattus norvegicus) | 6480464 | CTD | [Diethylnitrosamine co-treated with Hexachlorobenzene] results in increased expression of AHR protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AHR protein; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]] | PMID:15459018 PMID:20935162 PMID:22129741 PMID:22687989 PMID:26219504 | | ||||||||||||||||||||||
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