GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccnd1 | increases expression | EXP | | 127285675 | RGD | N-nitrosodiethylamine increases expression of Ccnd1 protein in liver | | Ccnd1 | increases expression | ISO | Ccnd1 (Rattus norvegicus) | 151356973 | RGD | N-nitrosodiethylamine increases expression of CcnD1 protein in rat liver | | Ccnd1 | increases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased expression of CCND1 mRNA; Diethylnitrosamine results in increased expression of CCND1 protein | PMID:18506893 PMID:18691550 PMID:19919837 PMID:20583210 PMID:24535843 PMID:27058323 PMID:27151938 PMID:29859236 | Ccnd1 | multiple interactions | EXP | | 6480464 | CTD | [Diethylnitrosamine co-treated with Cholic Acid] results in increased expression of CCND1 protein; [Diethylnitrosamine co-treated with Dietary Fats] affects the expression of CCND1 mRNA; [Diethylnitrosamine co-treated with Dietary Fats] affects the expression of CCND1 protein; [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CCND1 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA; ATM protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; Sorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] | PMID:17917374 PMID:18506893 PMID:18691550 PMID:18978307 PMID:19690152 PMID:19919837 PMID:20101389 PMID:20583210 PMID:27058323 PMID:27151938 PMID:29859236 PMID:30826251 | Ccnd1 | increases expression | ISO | Ccnd1 (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of CCND1; Diethylnitrosamine results in increased expression of CCND1 mRNA; Diethylnitrosamine results in increased expression of CCND1 protein | PMID:10906429 PMID:11831363 PMID:12175673 PMID:17055752 PMID:19254457 PMID:19638242 PMID:19822196 PMID:21554863 PMID:23665939 PMID:24012840 PMID:26589970 | Ccnd1 | multiple interactions | ISO | Ccnd1 (Rattus norvegicus) | 6480464 | CTD | 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; [Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of CCND1 promoter; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; Lycopene inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein]; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; Phenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] | PMID:10906429 PMID:12616621 PMID:14633663 PMID:18253720 PMID:18544905 PMID:19551842 PMID:21554863 PMID:23665939 PMID:24012840 PMID:25374375 | | ||||||||||||||||||||||
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