Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of CCND1, Diethylnitrosamine results in increased expression of CCND1 mRNA, Diethylnitrosamine results in increased expression of CCND1 protein

PMID:10906429, PMID:11831363, PMID:12175673, PMID:17055752, PMID:19254457, PMID:19638242, PMID:19822196, PMID:21554863, PMID:23665939, PMID:24012840, PMID:26589970
multiple interactionsEXP 6480464CTD5, 7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], 5, 7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], [Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein, [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein, [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 protein, [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of CCND1 promoter, [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA, IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA], lycopene inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein], malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], Phenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein], thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]

PMID:10906429, PMID:12616621, PMID:14633663, PMID:18253720, PMID:18544905, PMID:19551842, PMID:21554863, PMID:23665939, PMID:24012840, PMID:25374375
increases expressionISORGD:685576480464CTDDiethylnitrosamine results in increased expression of CCND1 mRNA, Diethylnitrosamine results in increased expression of CCND1 protein

PMID:18506893, PMID:18691550, PMID:19919837, PMID:20583210, PMID:24535843, PMID:27058323, PMID:27151938, PMID:29859236
multiple interactionsISORGD:685576480464CTD[Diethylnitrosamine co-treated with Cholic Acid] results in increased expression of CCND1 protein, [Diethylnitrosamine co-treated with Dietary Fats] affects the expression of CCND1 mRNA, [Diethylnitrosamine co-treated with Dietary Fats] affects the expression of CCND1 protein, [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCND1 mRNA, [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of CCND1 mRNA, [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA, ATM protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein], epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], Sorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA], XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]

PMID:17917374, PMID:18506893, PMID:18691550, PMID:18978307, PMID:19690152, PMID:19919837, PMID:20101389, PMID:20583210, PMID:27058323, PMID:27151938, PMID:29859236, PMID:30826251
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.