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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628846
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a8
Name: cytochrome P450, family 4, subfamily a, polypeptide 8
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a8multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP4A8 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP4A8 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4A8 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP4A8 mRNAPMID:18164116 PMID:18253720 PMID:22129741 PMID:28943392
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