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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1amultiple interactionsISOHif1a (Rattus norvegicus)6480464CTD[cobaltous chloride co-treated with Diethylnitrosamine] results in increased expression of HIF1A protein; [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A mRNA; [Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of HIF1A proteinPMID:11751435 PMID:19383236
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