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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CASP12 mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CASP12 mRNA, [DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of CASP12 mRNA

PMID:17602206, PMID:23830814, PMID:27048571
increases expressionISORGD:7314426480464CTDDiethylnitrosamine results in increased expression of CASP12 mRNA

PMID:24535843
multiple interactionsISORGD:7314426480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CASP12 mRNA

PMID:24535843
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.