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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61926
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gjb1
Name: gap junction protein, beta 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjb1affects response to substanceEXP 6480464CTDGJB1 protein affects the susceptibility to DiethylnitrosaminePMID:16243774
Gjb1decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of GJB1 mRNAPMID:2559087
Gjb1decreases response to substanceEXP 6480464CTDGJB1 protein results in decreased susceptibility to DiethylnitrosaminePMID:22569583
Gjb1multiple interactionsEXP 6480464CTD[DDT co-treated with Diethylnitrosamine] results in decreased expression of GJB1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of GJB1 mRNA; [Diethylnitrosamine co-treated with chlorendic acid] results in decreased expression of GJB1 protein; [Diethylnitrosamine co-treated with ciprofibrate] results in decreased expression of GJB1 protein; [Diethylnitrosamine co-treated with Clofibrate] results in increased expression of GJB1 protein; [Diethylnitrosamine co-treated with Dioxins] results in decreased expression of GJB1 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GJB1 protein; [Diethylnitrosamine co-treated with pirinixic acid] results in decreased expression of GJB1 protein; [Diethylnitrosamine co-treated with Tamoxifen] results in decreased expression of GJB1 proteinPMID:10550479 PMID:15885732 PMID:1973356
Gjb1affects response to substanceISOGjb1 (Mus musculus)6480464CTDGJB1 protein affects the susceptibility to DiethylnitrosaminePMID:11376700 PMID:12016140 PMID:14688024 PMID:15492231
Gjb1multiple interactionsISOGjb1 (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of and affects the localization of GJB1 protein; mitoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of and affects the localization of GJB1 protein]PMID:36037915
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