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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krt8increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of KRT8 mRNAPMID:19638242
Krt8multiple interactionsEXP 6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of and results in increased phosphorylation of KRT8 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of KRT8 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of KRT8 proteinPMID:14656948 PMID:16158176 PMID:19409407 PMID:20935162 PMID:28943392
Krt8increases expressionISOKrt8 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of KRT8 mRNAPMID:12771043
Krt8multiple interactionsISOKrt8 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of KRT8 protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT8 protein; [Phenobarbital co-treated with Diethylnitrosamine co-treated with Pregnenolone Carbonitrile] results in increased expression of KRT8 mRNAPMID:18978307 PMID:20101389 PMID:33398415
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