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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6pdincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of G6PDX mRNAPMID:19638242
G6pdmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of G6PD protein; [Diethylnitrosamine co-treated with Methapyrilene] results in increased expression of G6PD protein; [Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein; [Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of G6PD protein; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of G6PD protein; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of G6PDX mRNA; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of G6PD protein]PMID:16188247 PMID:28903497 PMID:28943392
G6pdincreases expressionISOG6pdx (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of G6PDX mRNAPMID:24535843
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