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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of CYP7A1 mRNA

PMID:19638242
multiple interactionsEXP 6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA, [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA, [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA

PMID:14656948, PMID:16158176, PMID:18253720
increases expressionISORGD:104586480464CTDDiethylnitrosamine results in increased expression of CYP7A1 mRNA

PMID:18691550
multiple interactionsISORGD:104586480464CTD[Diethylnitrosamine co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA, [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA, [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA, [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP7A1 mRNA, IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP7A1 mRNA]

PMID:17917374, PMID:18691550, PMID:24535843
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.