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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2463
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2a1
Name: cytochrome P450, family 2, subfamily a, polypeptide 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 proteinPMID:16246485
Cyp2a1increases expressionISOCyp2a22 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CYP2A22 mRNAPMID:21607683
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