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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1increases expression ISOBcl2l1 (Mus musculus)127285675RGDN-nitrosodiethylamine increases expression of Bcl2l1 mRNA in liver 
Bcl2l1increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of BCL2L1 mRNA; Diethylnitrosamine results in increased expression of BCL2L1 proteinPMID:21167192 PMID:21554863 PMID:22393308 PMID:31129132
Bcl2l1multiple interactionsEXP 6480464CTD5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; [Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BCL2L1 protein; [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; Fluorouracil inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; Plant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; Plant Oils inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]PMID:11749691 PMID:11915028 PMID:21167192 PMID:21554863 PMID:22393308 PMID:23830814 PMID:31129132
Bcl2l1increases expressionISOBcl2l1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of BCL2L1 mRNAPMID:21607683
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