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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2004
Species: Rattus norvegicus
RGD Object: Gene
Symbol: A2m
Name: alpha-2-macroglobulin
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2mdecreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of A2M mRNAPMID:20360939
A2mincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of A2M mRNA; Diethylnitrosamine results in increased expression of A2M proteinPMID:27565560 PMID:29698782
A2mmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of A2M promoter; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of A2M mRNA; caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]PMID:20360939 PMID:20935162 PMID:25374375 PMID:28943392
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