Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of FAS proteinPMID:20583210
Fasmultiple interactionsEXP 6480464CTDCTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of FAS protein]; Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]; S-allylcysteine inhibits the reaction [Diethylnitrosamine inhibits the reaction [FAS protein binds to FAS protein]]PMID:20583210 PMID:31067004
Fasmultiple interactionsISOFas (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS mRNA; [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS proteinPMID:19427195
Go Back to source page   Continue to Ontology report