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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348646
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A5decreases expressionISOCyp3a9 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in decreased expression of CYP3A13 mRNAPMID:19638242
CYP3A5increases expressionISOCyp3a13 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CYP3A13 mRNAPMID:17942915
CYP3A5multiple interactionsISOCyp3a9 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A13 mRNA; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP3A13 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP3A13 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP3A13 mRNAPMID:17602206 PMID:18164116 PMID:18253720 PMID:28943392
CYP3A5multiple interactionsISOCyp3a13 (Mus musculus)6480464CTDMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP3A13 mRNA]PMID:17942915
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