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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10708
Species: Mus musculus
RGD Object: Gene
Symbol: Hgf
Name: hepatocyte growth factor
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hgfdecreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of HGF proteinPMID:20583210
Hgfincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of HGF mRNAPMID:18691550
Hgfmultiple interactionsEXP 6480464CTDCTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of HGF protein]; MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HGF mRNA]PMID:18691550 PMID:20583210
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