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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732114
Species: Mus musculus
RGD Object: Gene
Symbol: Cfd
Name: complement factor D
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cfdincreases expressionEXP 6480464CTD1-Methyl-3-isobutylxanthine results in increased expression of CFD mRNAPMID:9564879
Cfdmultiple interactionsEXP 6480464CTD(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CFD mRNA]; [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased expression of CFD mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CFD mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CFD mRNA; [bisphenol S co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CFD mRNA; [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CFD mRNA; Calcitriol inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of CFD mRNA]PMID:23428407 PMID:26820058 PMID:26972250 PMID:27273607 PMID:9564879
Cfdmultiple interactionsISOCFD (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CFD mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CFD mRNAPMID:28628672
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