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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11215
Species: Mus musculus
RGD Object: Gene
Symbol: Raf1
Name: v-raf-leukemia viral oncogene 1
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1multiple interactionsISORaf1 (Rattus norvegicus)6480464CTD[FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]]; [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone results in increased phosphorylation of and results in increased activity of RAF1 protein]PMID:21177760
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