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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:34785
Term: heptachlor
Definition: A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations.
Chemical ID: MESH:D006533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDHeptachlor results in increased expression of TGFB1 mRNAPMID:30719927
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTDHeptachlor inhibits the reaction [TGFB1 protein results in increased localization of CYCS protein]PMID:14678745
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