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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11484
Species: Mus musculus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Acc ID: CHEBI:34778
Term: glycitein
Definition: A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.
Chemical ID: MESH:C086566
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDglycitein results in increased expression of VDR mRNA; glycitein results in increased expression of VDR proteinPMID:17088408
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [glycitein results in increased expression of VDR protein]; glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased expression of VDR protein]PMID:17088408
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