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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:34757
Term: fenitrothion
Definition: An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Chemical ID: MESH:D005278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISOCYP2B6 (Homo sapiens)6480464CTDFenitrothion results in decreased activity of CYP2B6 proteinPMID:20183062 PMID:22310298 PMID:22634058
Cyp2b3increases expressionISOCYP2B6 (Homo sapiens)6480464CTDFenitrothion results in increased expression of CYP2B6 mRNAPMID:22310298
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTDFenitrothion inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]PMID:22634058
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