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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732102
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Acc ID: CHEBI:34732
Term: E-4031
Definition: A sulfonamide that has formula C21H27N3O3S.
Chemical ID: MESH:C063968
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects bindingISOKCNH2 (Homo sapiens)6480464CTDE 4031 binds to KCNH2 proteinPMID:19260734
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDE 4031 affects the localization of KCNH2 protein mutant formPMID:11741928
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDE 4031 results in decreased activity of KCNH2 proteinPMID:11741928 PMID:12359267 PMID:14709917 PMID:16494862 PMID:16757186 PMID:17513944 PMID:18724381 PMID:20050851 PMID:23707769 PMID:24052561
Kcnh2increases activityISOKCNH2 (Homo sapiens)6480464CTDE 4031 results in increased activity of KCNH2 protein mutant formPMID:10531299
Kcnh2multiple interactionsISOKcnh2 (Rattus norvegicus)6480464CTDE 4031 inhibits the reaction [Progesterone results in decreased localization of KCNH2 protein]PMID:21525004
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTD[KCNE2 protein binds to KCNH2 protein] which results in increased susceptibility to E 4031; beta-Cyclodextrins analog inhibits the reaction [E 4031 results in decreased activity of KCNH2 protein]; E 4031 binds to and results in decreased activity of KCNH2 protein; E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]; E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; E 4031 inhibits the reaction [Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 results in decreased activity of [KCNE2 protein binds to KCNH2 protein]; E 4031 results in increased glycosylation of and affects the localization of KCNH2 protein mutant formPMID:10219239 PMID:10531299 PMID:12070109 PMID:12359267 PMID:15272206 PMID:17513944 PMID:19583963 PMID:21158687
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