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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4increases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of TLR4 mRNA; Dinitrochlorobenzene results in increased expression of TLR4 proteinPMID:31226360
TLR4multiple interactionsEXP 6480464CTDTLR4 protein promotes the reaction [Dinitrochlorobenzene results in increased phosphorylation of RELA protein]PMID:31226360
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