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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4affects expressionISOIl4 (Mus musculus)6480464CTDDinitrochlorobenzene affects the expression of IL4 mRNAPMID:22302311
Il4decreases expressionISOIl4 (Mus musculus)6480464CTDDinitrochlorobenzene results in decreased expression of IL4 mRNA; Dinitrochlorobenzene results in decreased expression of IL4 proteinPMID:34651546
Il4increases expressionISOIl4 (Mus musculus)6480464CTDDinitrochlorobenzene results in increased expression of IL4 mRNA; Dinitrochlorobenzene results in increased expression of IL4 proteinPMID:15588918 PMID:15664275 PMID:18652873 PMID:19422874 PMID:23133493 PMID:23200891 PMID:23454147 PMID:28826779 PMID:29233007
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTD[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL4 mRNA; Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL4 mRNA]; Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 protein]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 protein]; sulforaphane inhibits the reaction [Dinitrochlorobenzene results in decreased expression of IL4 mRNA]; sulforaphane inhibits the reaction [Dinitrochlorobenzene results in decreased expression of IL4 protein]PMID:23133493 PMID:23200891 PMID:23454147 PMID:23499868 PMID:34651546
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