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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of IL6 mRNA; Dinitrochlorobenzene results in increased expression of IL6 proteinPMID:18652873 PMID:19647056
Il6increases secretionEXP 6480464CTDDinitrochlorobenzene results in increased secretion of IL6 proteinPMID:22245253
Il6multiple interactionsEXP 6480464CTD[Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IL6 mRNA; Lipopolysaccharides promotes the reaction [Dinitrochlorobenzene results in increased expression of IL6 mRNA]PMID:12202904 PMID:16687389
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased expression of IL6 mRNAPMID:11378323
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased secretion of IL6 proteinPMID:28941582
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Dinitrochlorobenzene] results in increased expression of and results in increased secretion of IL6 proteinPMID:24964617
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