GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP19A1 | increases expression | EXP | | 6480464 | CTD | diethyl phthalate results in increased expression of CYP19A1 protein | PMID:24994688 | CYP19A1 | multiple interactions | EXP | | 6480464 | CTD | diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]] | PMID:24994688 | CYP19A1 | increases expression | ISO | Cyp19a1 (Rattus norvegicus) | 6480464 | CTD | diethyl phthalate results in increased expression of CYP19A1 mRNA; diethyl phthalate results in increased expression of CYP19A1 protein | PMID:24994688 | CYP19A1 | multiple interactions | ISO | Cyp19a1 (Mus musculus) | 6480464 | CTD | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate] results in decreased expression of CYP19A1 mRNA | PMID:28013214 PMID:34597818 | |
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