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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:34698
Term: diethyl phthalate
Definition: The diethyl ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C007379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1increases expressionEXP 6480464CTDdiethyl phthalate results in increased expression of CYP19A1 proteinPMID:24994688
CYP19A1multiple interactionsEXP 6480464CTDdiethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]PMID:24994688
CYP19A1increases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDdiethyl phthalate results in increased expression of CYP19A1 mRNA; diethyl phthalate results in increased expression of CYP19A1 proteinPMID:24994688
CYP19A1multiple interactionsISOCyp19a1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate] results in decreased expression of CYP19A1 mRNAPMID:28013214 PMID:34597818
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