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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:34696
Term: dieldrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.
Chemical ID: MESH:D004026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNdecreases response to substanceEXP 6480464CTDJUN gene mutant form results in decreased susceptibility to DieldrinPMID:32421776
JUNincreases expressionEXP 6480464CTDDieldrin results in increased expression of JUN mRNAPMID:31068361
JUNincreases phosphorylationEXP 6480464CTDDieldrin results in increased phosphorylation of JUN proteinPMID:15888667
JUNaffects expressionISOJun (Rattus norvegicus)6480464CTDDieldrin affects the expression of JUN mRNAPMID:22546817
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