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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:34693
Term: Dicyclohexyl phthalate
Definition: A phthalate ester that has formula C20H26O4.
Chemical ID: MESH:C036042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDdicyclohexyl phthalate binds to and results in increased activity of ESR1 protein; dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein]PMID:15840436 PMID:28571686 PMID:28717100
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