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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:34690
Term: dichlorvos
Definition: An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.
Chemical ID: MESH:D004006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDDichlorvos results in decreased activity of GSR proteinPMID:20302853 PMID:22224058 PMID:22751200
Gsrdecreases expressionEXP 6480464CTDDichlorvos results in decreased expression of GSR proteinPMID:18539328
Gsrincreases activityEXP 6480464CTDDichlorvos results in increased activity of GSR proteinPMID:25895260
Gsrmultiple interactionsEXP 6480464CTD[Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; Dichlorvos inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Plant Extracts inhibits the reaction [Dichlorvos results in decreased activity of GSR protein]; sodium arsenite inhibits the reaction [Dichlorvos results in increased activity of GSR protein]PMID:22224058 PMID:25895260
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