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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605110
Species: Homo sapiens
RGD Object: Gene
Symbol: KEAP1
Name: kelch like ECH associated protein 1
Acc ID: CHEBI:34688
Term: dichloroacetyl chloride
Definition: The acyl chloride obtained by displacement of the hydroxy group of dichloroacetic acid by chloride.
Chemical ID: MESH:C053063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KEAP1increases expressionISOKeap1 (Mus musculus)6480464CTD2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA; 2,2-dichloroacetyl chloride results in increased expression of KEAP1 proteinPMID:32073640
KEAP1multiple interactionsISOKeap1 (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]PMID:32073640
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