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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737482
Species: Homo sapiens
RGD Object: Gene
Symbol: BIRC5
Name: baculoviral IAP repeat containing 5
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BIRC5decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of BIRC5 mRNAPMID:28973377
BIRC5increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of BIRC5 mRNAPMID:36828243
BIRC5multiple interactionsEXP 6480464CTDN-methyl-delta-3,3-dihydroindole-2,2 diketone inhibits the reaction [Dibutyl Phthalate results in increased expression of BIRC5 mRNA]PMID:36828243
BIRC5decreases expressionISOBirc5 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in decreased expression of BIRC5 mRNAPMID:21266533
BIRC5decreases expressionISOBirc5 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of BIRC5 mRNA; Dibutyl Phthalate results in decreased expression of BIRC5 proteinPMID:17361019 PMID:33336902
BIRC5increases expressionISOBirc5 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased expression of BIRC5 mRNAPMID:17379624
BIRC5multiple interactionsISOBirc5 (Mus musculus)6480464CTDNimodipine inhibits the reaction [Dibutyl Phthalate results in decreased expression of BIRC5 protein]PMID:33336902
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