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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925
Species: Homo sapiens
RGD Object: Gene
Symbol: GJA1
Name: gap junction protein alpha 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJA1increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of GJA1 mRNA; Dibutyl Phthalate results in increased expression of GJA1 proteinPMID:37356649
GJA1multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 mRNA]; dorsomorphin inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 protein]; GJA1 protein promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]; Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 protein]PMID:37356649
GJA1decreases expressionISOGja1 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of GJA1 mRNA; Dibutyl Phthalate results in decreased expression of GJA1 proteinPMID:21266533 PMID:33331133
GJA1decreases expressionISOGja1 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in decreased expression of GJA1 mRNAPMID:21266533
GJA1multiple interactionsISOGja1 (Mus musculus)6480464CTDginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 mRNA]; ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased expression of GJA1 protein]PMID:33331133
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