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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of CYP11A1 mRNA

PMID:28104404
decreases expressionISORGD:693256480464CTDDibutyl Phthalate results in decreased expression of CYP11A mRNA, Dibutyl Phthalate results in decreased expression of CYP11A protein, Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA, Dibutyl Phthalate results in decreased expression of CYP11A1 protein

PMID:14617579, PMID:15141095, PMID:15987825, PMID:16037377, PMID:17379624, PMID:17884934, PMID:21266533, PMID:21745491, PMID:22615892, PMID:26706031, PMID:26948521, PMID:26961603, PMID:27079746, PMID:28528174
decreases expressionISORGD:7356326480464CTDDibutyl Phthalate results in decreased expression of CYP11A1 mRNA

PMID:29029336
increases expressionISORGD:693256480464CTDDibutyl Phthalate results in increased expression of CYP11A1 mRNA

PMID:26472102
multiple interactionsISORGD:693256480464CTD[Dexamethasone co-treated with Dibutyl Phthalate] results in decreased expression of CYP11A1 mRNA, [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP11A1, Dibutyl Phthalate inhibits the reaction [CEBPB binds to CYP11A1 promoter], Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP11A1 promoter], Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP11A1 promoter]

PMID:17400582, PMID:17884934, PMID:22615892, PMID:23358192
multiple interactionsISORGD:7356326480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA, [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA

PMID:28013214, PMID:29029336
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.