GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Dibutyl Phthalate results in increased expression of NFE2L2 mRNA; Dibutyl Phthalate results in increased expression of NFE2L2 protein | PMID:21266533 PMID:28295950 PMID:30910607 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Dibutyl Phthalate results in increased expression of NFE2L2 protein]; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of NFE2L2 mRNA; [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with Diethylhexyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in increased expression of NFE2L2 mRNA; [sulforaphane co-treated with Dibutyl Phthalate] results in increased expression of NFE2L2 protein; NFE2L2 protein affects the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein]; NFE2L2 protein affects the reaction [Dibutyl Phthalate results in increased activity of CASP3 protein]; NFE2L2 protein affects the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; NFE2L2 protein affects the reaction [Dibutyl Phthalate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dibutyl Phthalate results in increased expression of NQO1 protein] | PMID:28295950 PMID:30910607 PMID:37021957 PMID:37364641 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | Dibutyl Phthalate results in increased expression of NFE2L2 protein | PMID:30910607 PMID:35690178 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Dibutyl Phthalate results in increased expression of NFE2L2 protein] | PMID:30910607 | | ||||||||||||||||||||||
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