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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of CTNNB1 mRNA; Dibutyl Phthalate results in increased expression of CTNNB1 proteinPMID:30053495 PMID:36308879
Ctnnb1multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA]PMID:30053495
Ctnnb1affects localizationISOCTNNB1 (Homo sapiens)6480464CTDDibutyl Phthalate affects the localization of CTNNB1 proteinPMID:22552774
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTDHDAC6 mutant form inhibits the reaction [Dibutyl Phthalate affects the localization of CTNNB1 protein]; trichostatin A inhibits the reaction [Dibutyl Phthalate affects the localization of CTNNB1 protein]PMID:22552774
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