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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62161
Species: Mus musculus
RGD Object: Gene
Symbol: Grb14
Name: growth factor receptor bound protein 14
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grb14increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of GRB14 mRNAPMID:17361019 PMID:21266533
Grb14affects expressionISOGrb14 (Rattus norvegicus)6480464CTDDibutyl Phthalate affects the expression of GRB14 proteinPMID:21745491
Grb14increases expressionISOGrb14 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased expression of GRB14 mRNA; Dibutyl Phthalate results in increased expression of GRB14 proteinPMID:15728792 PMID:21266533 PMID:21745491
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