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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationEXP 6480464CTDDibutyl Phthalate results in decreased phosphorylation of MAPK3 proteinPMID:26133781
MAPK3increases phosphorylationEXP 6480464CTDDibutyl Phthalate results in increased phosphorylation of MAPK3 proteinPMID:36089060
MAPK3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK3 protein; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Dibutyl Phthalate] results in decreased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of MAPK3 protein]PMID:26133781 PMID:36089060
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of MAPK3 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased phosphorylation of MAPK3 protein; [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK3 protein]; Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]PMID:30776390 PMID:33336902 PMID:35739755 PMID:37364641
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